<Core Guardian>
Level 100 ^^^
Watch for the red text 'The Amalgam of Energy's core begins to overload! You can feel energy being ripped from the very air around you.'. Energy Globules will spawn around the edge of the room (4 at the 75% threshold, 6 at the 50% threshold and 8 at the 25% threshold) and slowly travel toward the boss and will heal it for 26.8 million HP for each one that makes it.
As long as any Energy Globules remain alive the Amalgam of Energy is immune to all damage.