First Boss.
Targets on ground harm you and heal boss.
DEATH TOUCH Gain stacks which reduce your DPS and 10 stacks=DEAD.
Heroic Opportunity clears stacks
Fourth Boss.
Use Heroic Opportunity to remove damage reduction buff.
Cure Tail Snap detrimental to avoid big AE.
Let him eat you (don't cure his detriment) for POI achievement.